melanoma

[Scientific Reports] To study Hsp70 forms released from cells scientists employed the assay consisting of two affinity chromatography methods. Hsp70 content in culture medium and extracellular vesicles was measured with the aid of ELISA.

[Nature Communications] The authors showed in mouse melanoma and breast cancer models that regulatory T cells expressing the β8 chain of αvβ8 integrin are the main cell type in the tumors that activated TGFβ, produced by the cancer cells and stored in the tumor micro-environment.

[Nature Communications] Scientists showed in mouse melanoma and breast cancer models that regulatory T cells expressing the β8 chain of αvβ8 integrin were the main cell type in the tumors that activated TGFβ, produced by the cancer cells and stored in the tumor microenvironment.

[GenFleet Therapeutics] GenFleet Therapeutics announced the first patient with metastatic sigmoid adenocarcinoma has been dosed in a Phase Ib/II trial of GFH018 in combination with toripalimab as part of global multi-center clinical research. There are broad indications for GFH018 in treating solid tumors with lower response rates to PD-1 inhibitors.

[Cell Reports] Investigators reported that mucolipin TRP channel 1, a lysosomal Ca2+ and Zn2+ release channel that regulated multiple aspects of lysosome function, was dramatically upregulated in metastatic melanoma cells compared with normal cells.

[Nature] Investigators showed that in mouse melanoma models, depleted KDM5B—an H3K4 demethylase that was critical for melanoma maintenance and drug resistance—induced robust adaptive immune responses and enhanced responses to immune checkpoint blockades.