melanoma

[Oncogene] The authors observed coordinate expression of IER2, p53/p21, and osteopontin in primary human melanomas and metastases, which highlighted the pathophysiological relevance of IER2-mediated senescence in melanoma progression.

[Scientific Reports] Sgc8-c was evaluated in a metastatic melanoma model as molecular imaging probe for in vivo diagnostic, and two probes were in vitro evaluated verifying the high specific PTK7 recognition and its internalization in tumor cells by the endosomal route.

[Scientific Reports] Researchers investigated the significance of sPD-L1 in cancer patients receiving immune checkpoint inhibitor therapy.

[Scientific Reports] Scientists showed that systemic delivery of tumor-associated antigens facilitated in vivo priming and expansion of previously non-activated T cells and enhanced the cytotoxicity of activated T cells.

[Bristol Myers Squibb] Bristol Myers Squibb announced Marketing Authorization Application (MAA) validation for the LAG-3-blocking antibody relatlimab and nivolumab fixed-dose combination for first-line treatment of adult and pediatric patients with advanced (unresectable or metastatic) melanoma.

[Acta Pharmaceutica Sinica B] Scientists demonstrated that physapubenolide (PB) inhibited cell proliferation and migration in melanoma cells by inducing cell apoptosis. They explored the mechanism underlying the anticancer effects of PB through an in silico target prediction study.