mesenchymal stem cells

[Molecular Neurobiology] Investigators evaluated the effects of human umbilical cord mesenchymal stem cell-conditioned medium in a new in vitro model of neurons differentiated from Dravet syndrome patient-derived iPSCs.

[Frontiers in Cell and Developmental Biology] The authors used a tripartite model of human hepatocellular carcinoma cell line and mesenchymal stromal cells co-cultured with peripheral blood mononuclear cells to investigate the impact of tumor and stromal cell interactions to the development of immunosuppressive tumor microenvironment.

[Scientific Reports] Researchers assessed the cellular sensitivity of magnetic particle imaging and fluorine-19 magnetic resonance imaging for detection of MSCs and breast cancer cells.

[Cell Death Discovery] Investigators isolated radiation-induced senescent tdTOMp16 positive MSCs, established their absence of cell division, then measured levels of irradiation-induced expression of biomarkers of senescence by RNA-seq analysis.

[Laboratory Investigation] MSCs were genetically modified to overexpress placental growth factor, and its effects on macrophage proliferation and polarization were analyzed in vitro in a transwell co-culture system, as well as in vivo in a mouse model for spinal fusion, for which the cells were bilaterally injected into paravertebral muscles of the mouse lumbar spine.

[Nature Communications] Deletion of the apoptotic effectors BAK and BAX prevented MSC death and attenuated their immunosuppressive effects in disease models used to define MSC potency.