mesenchymal stem cells

[Bmj Open] Investigators developed a Phase IIb, multicentre, randomized, double-blind, placebo-controlled clinical trial protocol to evaluate the safety and efficacy of intravenous administration of allogeneic adipose tissue-derived MSCs in patients with acute ischaemic stroke, concurrently with conventional stroke treatment.

[Stem Cell Research & Therapy] The authors analyzed hypoxia impact on human and pig bone marrow-derived MSCs and mouse myoblast proliferation, differentiation, and fusion.

[Journal of Materials Chemistry B] Scientists investigated the efficacy of endothelial cell (EC)-seeded nanofibrous scaffolds in improving vascularization in vivo. ECs derived from induced human Wharton's Jelly mesenchymal stem cells served as a potential source for cell transplantation.

[Journal of Tissue Viability] The authors revealed that the NRF2-conditioned medium protected the wharton's jelly derived-MSCs against H2O2-induced toxicity in vitro.

[Stem Cell Research & Therapy] The authors describe the basic characteristics and biological functions of menstrual blood-derived MSCs-derived small extracellular vesicles.

[Stem Cells Translational Medicine] Scientists determined the ratio of patients whose synovial MSCs were transplanted clinically, to intensively investigate MSCs with trisomy 7 from a safety perspective, and to follow up the patients for five years after transplantation.