Scientists investigated the efficacy of endothelial cell (EC)-seeded nanofibrous scaffolds in improving vascularization in vivo. ECs derived from induced human Wharton’s Jelly mesenchymal stem cells served as a potential source for cell transplantation.
[Journal of Materials Chemistry B]
6445218 {6445218:6YMKTZYW} apa 50 1 165518 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-a847fb52517f29b729fd3728d5689071%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%226YMKTZYW%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Li%20et%20al.%22%2C%22parsedDate%22%3A%222021-07-19%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELi%2C%20X.%2C%20You%2C%20R.%2C%20Zhang%2C%20Q.%2C%20Yan%2C%20S.%2C%20Luo%2C%20Z.%2C%20Qu%2C%20J.%2C%20%26amp%3B%20Li%2C%20M.%20%282021%29.%20Engineering%20vascularized%20dermal%20grafts%20by%20integrating%20a%20biomimetic%20scaffold%20and%20Wharton%26%23x2019%3Bs%20jelly%20MSC-derived%20endothelial%20cells.%20%3Ci%3EJournal%20of%20Materials%20Chemistry%20B%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1039%5C%2FD1TB00857A%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1039%5C%2FD1TB00857A%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3D6YMKTZYW%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Engineering%20vascularized%20dermal%20grafts%20by%20integrating%20a%20biomimetic%20scaffold%20and%20Wharton%27s%20jelly%20MSC-derived%20endothelial%20cells%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiufang%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Renchuan%22%2C%22lastName%22%3A%22You%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiang%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Shuqin%22%2C%22lastName%22%3A%22Yan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zuwei%22%2C%22lastName%22%3A%22Luo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jing%22%2C%22lastName%22%3A%22Qu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mingzhong%22%2C%22lastName%22%3A%22Li%22%7D%5D%2C%22abstractNote%22%3A%22Tissue%20engineering%20aims%20to%20generate%20functional%20tissue%20constructs%20with%20the%20necessary%20scaffold%20properties%20for%20cell%20colonization%20and%20the%20establishment%20of%20a%20vascular%20network.%20However%2C%20treatment%20of%20tissue%20defects%20using%20synthetic%20scaffolds%20remains%20a%20challenge%20mainly%20due%20to%20insufficient%20and%20slow%20vascularization.%20Our%20previous%20study%20developed%20a%20macroporous%20silk%20fibroin%20scaffold%20with%20a%20nanofibrous%20microstructure%2C%20and%20demonstrated%20that%20the%20nanofibrous%20structure%20can%20promote%20the%20viability%20of%20endothelial%20cells%20%28ECs%29%20and%20guide%20cell%20migration.%20Further%20studies%20are%20needed%20to%20clarify%20the%20effect%20of%20scaffold%20microstructures%20on%20cell-mediated%20vascularization.%20Here%2C%20we%20investigated%20the%20efficacy%20of%20EC-seeded%20nanofibrous%20scaffolds%20in%20improving%20vascularization%20in%20vivo.%20ECs%20derived%20from%20induced%20human%20Wharton%27s%20Jelly%20mesenchymal%20stem%20cells%20served%20as%20a%20potential%20source%20for%20cell%20transplantation.%20The%20cell-seeded%20scaffolds%20were%20implanted%20into%20dermal%20defects%20of%20SD%20rats%2C%20demonstrating%20that%20the%20multiscale%20hierarchical%20design%20significantly%20improved%20the%20capacity%20of%20transplanted%20cells%20to%20promote%20and%20accelerate%20neovascularization%20and%20dermal%20reconstruction%20via%20enhancing%20cell%20infiltration%2C%20collagen%20deposition%20and%20growth%20factor%20expression.%20Our%20findings%20provide%20new%20insight%20into%20the%20development%20of%20degradable%20macroporous%20composite%20materials%20with%203D%20microstructures%20as%20tissue%20engineering%20scaffolds%20with%20enhanced%20vascularization%20functions%2C%20and%20also%20provide%20new%20treatment%20options%20for%20cell%20transplantation.%22%2C%22date%22%3A%222021-07-19%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1039%5C%2FD1TB00857A%22%2C%22ISSN%22%3A%222050-7518%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubs.rsc.org%5C%2Fen%5C%2Fcontent%5C%2Farticlelanding%5C%2F2021%5C%2Ftb%5C%2Fd1tb00857a%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-08-10T03%3A16%3A29Z%22%7D%7D%5D%7D
Li, X., You, R., Zhang, Q., Yan, S., Luo, Z., Qu, J., & Li, M. (2021). Engineering vascularized dermal grafts by integrating a biomimetic scaffold and Wharton’s jelly MSC-derived endothelial cells. Journal of Materials Chemistry B. https://doi.org/10.1039/D1TB00857A Cite