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mesenchymal stem cells

Dermal Mesenchymal Stem Cells from Psoriatic Lesions Stimulate HaCaT Cell Proliferation, Differentiation, and Migration via Activating the PI3K/AKT Signaling Pathway

[Dermatology] Scientists studied the effects of psoriatic dermal mesenchymal stem cells on the proliferation, differentiation, and migration of keratinocytes and the underlying mechanisms.

Therapeutic Aspects of Mesenchymal Stem Cell-Based Cell Therapy with a Focus on Human Amniotic Epithelial Cells in Multiple Sclerosis: A Mechanistic Review

[World Journal of Stem Cells] The authors discuss the mechanistic effects of MSCs with a focus on human amniotic epithelial cells, which can be used to treatment and improvement of outcome in multiple sclerosis disease.

Importance of the Origin of Mesenchymal (Stem) Stromal Cells in Cancer Biology: “Alliance” or “War” in Intercellular Signals

[Cell & Bioscience] Research attributes both pro-tumor and anti-tumor actions to mesenchymal stem cells (MSCs); however, evidence indicates that MSCs specific effect on the tumor depends on the source of the MSCs and the type of tumor.

Inverse and Reciprocal Regulation of p53/p21 and BMI-1 Modulates Vasculogenic Differentiation of Dental Pulp Stem Cells

[Cell Death & Disease] Dental pulp stem cells seeded in biodegradable scaffolds and transplanted into immunodeficient mice generated mature human blood vessels invested with smooth muscle actin-positive mural cells.

Cell-Fate Decision of Mesenchymal Stem Cells toward Osteocyte Differentiation Is Committed by Spheroid Culture

[Scientific Reports] While the osteocytes are known as terminally differentiated cells derived from MSCs, the detailed mechanisms of osteocyte differentiation remain unclear. Scientists fabricated 3D self-organized spheroids using human MSCs.

Effect of Expansion Media and Fibronectin Coating on Growth and Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stromal Cells

[Scientific Reports] The use of a xenogeneic-free medium provided a suitable alternative for human bone marrow MSC expansion, due the capability to maintain cell characteristic and potency.

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