microglia

[Science Advances] Scientists reported that at 24 hours after ischemia, microglia released brain-derived neurotrophic factor to downregulate glutamatergic and GABAergic synapses within the peri-infarct area.

[Glia] Investigators described an approach to derive microglia from human induced pluripotent stem cells (iPSCs) and integrated them into iPSC-derived midbrain organoids.

[Frontiers in Cell and Developmental Biology] Beneficial effects were observed with Rapamycin treatment as it decreased the gliotic response and prevented the development of newly formed blood vessels.

[Brain] Investigators reinforced the connection between aberrant cytosolic-to-endoplasmic reticulum acetyl-CoA flux and the development of an autistic-like phenotype.

[Acta Pharmacologica Sinica] Investigators describe in detail the damage-associated molecular patterns that induce or aggravate neuroinflammation in neurodegenerative diseases including mtDNA, mitochondrial unfolded protein response, mitochondrial reactive oxygen species, adenosine triphosphate, transcription factor A mitochondria, cardiolipin, cytochrome c, mitochondrial Ca2+ and iron.

[Signal Transduction and Targeted Therapy] Scientists indicated that targeting IL6/JAK2/STAT3 signaling in activated microglia might be a promising new approach for inhibiting brain metastasis in NSCLC patients.