monocytes

[Cellular & Molecular Immunology] Researchers addressed the question of whether liver macrophage restoration resulted from circulating monocyte infiltration or local kupffer cell proliferation in regenerating livers after partial hepatectomy (PHx) and uncovered the underlying mechanisms.

[Stem Cell Reports] Both human pluripotent stem cell-derived cardiomyocytes and adult cardiomyocytes could be productively infected by SARS-CoV-2, leading to secretion of the monocyte chemoattractant cytokine CCL2 and subsequent monocyte recruitment.

[Communications Biology] The authors observed fewer tumor foci in Ncf1 mutant mice, irrespective of αβT, γδT, B-cell deficiencies, or of a functional Ncf1 expression in CD68-positive monocytes/macrophages.

[Scientific Reports] The authors studied the gene expression and function in systemic-onset juvenile idiopathic arthritis to assess the biological role of CD71+ erythroid cells in systemic inflammation.

[Signal Transduction and Targeted Therapy] Scientists demonstrated that the expression of KLF2 was reduced and monocyte adhesion was increased in endothelial cells treated with COVID-19 patient serum due to elevated levels of pro-adhesive molecules, ICAM1 and VCAM1.

[International Immunopharmacology] Scientists showed that TNF-α significantly reduced the expression of SIRT6 protein and mRNA in a concentration- and time-dependent manner and increased the expression of monocyte chemotactic protein 1, interleukin (IL) -6 and IL-1β in human umbilical vein endothelial cells.