muscle cells

[eLife] The authors found that the number and size of sarcoplasmic reticulum (SR)-plasma membrane interacting sites were decreased, and SR-dependent Ca2+ signaling processes were disrupted in freshly isolated cerebral artery SMCs from tamoxifen-inducible, SMC-specific STIM1-knockout mice.

[Biophysical Journal] Scientists engineered ribonucleotide reductase overexpressing human-induced pluripotent stem cell-derived cardiomyocytes as a novel cell therapy strategy to improve contractility and regeneration in myocardial infarction.

[Arteriosclerosis Thrombosis and Vascular Biology] Scientists discuss key findings from the latest research that give insight into the mechanisms by which clonal expansion of vascular cells contributes to disease pathology.

[Cell Death & Disease] Knockdown of myocardin (MYOCD) in human aortic VSMCs triggered autophagy and diminished the expression of SMC contractile proteins. Inhibition of autophagy in MYOCD-knockdown cells restored the expression of contractile proteins.

[Cell Discovery] To delineate the cellular and molecular changes during the development of thoracic aortic aneurysm and dissection (TAAD), scientists performed single-cell RNA sequencing of thoracic aortic cells from β-aminopropionitrile-induced TAAD mouse models at three time points that spanned from the early to the advanced stages of the disease.

[Journal of Cellular Physiology] Scientists observed that apelin-13-induced cardiomyocyte hypertrophy by activating FAM134B-dependent reticulophagy via the Pannexin-1/P2X7 signal pathway.