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muscle cells

CDH18 Is a Fetal Epicardial Biomarker Regulating Differentiation towards Vascular Smooth Muscle Cells

[NPJ Regenerative Medicine] Scientists recapitulated epicardiogenesis using human iiPSCs and identified type II classical cadherin CDH18 as a biomarker defining lineage specification in human active epicardium.

Human iPSC Model Reveals a Central Role for NOX4 and Oxidative Stress in Duchenne Cardiomyopathy

[Stem Cell Reports] The authors used Duchenne muscular dystrophy-patient-specific human iPSCs to model cardiomyopathic features and unravel novel pathologic insights.

In Vitro Matured Human Pluripotent Stem Cell-Derived Cardiomyocytes Form Grafts With Enhanced Structure and Function in Injured Hearts

[Circulation] The authors comprehensively phenotyped human PSC-cardiomyocytes after in vitro maturation for 20 and 40 days on either polydimethylsiloxaneor standard tissue culture plastic substrates.

Baicalin Alleviates Thrombin-Induced Inflammation in Vascular Smooth Muscle Cells

[Biomed Research International] Researchers investigated the capacity for thrombin to trigger inflammation and induce cell proliferation in vascular smooth muscle cells.

Ubiquitinated AIF Is a Major Mediator of Hypoxia-Induced Mitochondrial Dysfunction and Pulmonary Artery Smooth Muscle Cell Proliferation

[Cell & Bioscience] Scientists investigated the specific involvement of apoptosis-inducing factor, a mitochondrial oxidoreductase in regulating mitochondrial energy metabolism and mitophagy in pulmonary artery smooth muscle cells.

Generating 3D Human Cardiac Constructs from Pluripotent Stem Cells

[Ebiomedicine] Scientists discuss the advantages and limitations of 2D human pluripotent stem cell (hPSC)-cardiomyocyte system, and introduce the recent development of three-dimensional culture platforms derived from hPSCs.

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