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muscle cells

Epigallocatechin Gallate Facilitates Extracellular Elastin Fiber Formation in Induced Pluripotent Stem Cell Derived Vascular Smooth Muscle Cells for Tissue Engineering

[Journal of Molecular and Cellular Cardiology] Researchers established the ability of the polyphenol compound epigallocatechin gallate, a principal component of green tea, to facilitate the extracellular formation of elastin fibers in vascular smooth muscle cells derived from human induced pluripotent stem cells.

Dysregulation of Interaction between LOXhigh Fibroblast and Smooth Muscle Cells Contributes to the Pathogenesis of Aortic Dissection

[Theranostics] By use of single-cell RNA-sequencing and multi-color staining, scientists delineated the cellular composition and spatial characterization of human aorta with or without aortic dissection.

Inhibitors of the MAPK/ NF-κB Pathway Attenuate the Upregulation of the ETB Receptor Mediated by High Glucose in Vascular Smooth Muscle Cells

[Peptides] Researchers investigated the mechanism of high glucose-induced endothelin type B (ETB) receptors in vascular smooth muscle cell.

LDHA Mediated Degradation of Extracellular Matrix Is a Potential Target for the Treatment of Aortic Dissection

[Pharmacological Research] Researchers found that the level of lactate dehydrogenase A (LDHA) was significantly elevated in aortic dissection patients and the mouse model established by BAPN combined with Ang II.

Transforming Growth Factor-β in Myocardial Disease

[Nature Reviews Cardiology] The authors summarize the current evidence on the role of TGFβ signaling in myocardial diseases, focusing on cellular targets and molecular mechanisms, and discuss challenges and opportunities for therapeutic translation.

Interaction of SARS-CoV-2 with Cardiomyocytes: Insight into the Underlying Molecular Mechanisms of Cardiac Injury and Pharmacotherapy

[Biomedicine & Pharmacotherapy] The authors provide an overview of the pathways involved with cardiomyocyte in COVID-19 subjects to help promoting pharmacotherapies that can protect against SARS-CoV-2-induced cardiac injuries.

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