muscle cells

[Experimental & Molecular Medicine] Researchers identified and functionally validated a long noncoding RNAs using human atherosclerotic plaques. Human aortic samples were obtained from patients who underwent aortic surgery, and tissues were classified according to atherosclerotic plaques.

[Acta Pharmacologica Sinica] In vitro, scientists found that DAPA inhibited the expression of cleaved caspase 3, Bax, C/EBP homologous protein (CHOP), and glucose-regulated protein78 (GRP78) and upregulated the cardiomyoprotective protein Bcl-2 in angiotensin II (Ang II)-treated cardiomyocytes.

[Journal of Clinical Investigation] Scientists showed that rescue of pyrimidine biosynthesis by administration of uridine or by genetic targeting of ENPP1/AMP pathway enhanced repair after cardiac injury.

[Journal of Cellular Physiology] Researchers identified the potential roles of glycogen synthase kinase-3β, a critical regulator of cell proliferation and differentiation, in cardiac progenitor cell proliferation post-myocardial infarction.

[Molecular Medicine Reports] The authors explored the role and molecular mechanism of lncRNA small nucleolar RNA host gene 1 (SNHG1) in ischemic cardiomyocyte injury.

[Journal of Physiology] Using a comprehensive combination of genetically modified fish, electrophysiology, and gene expression analysis, scientists demonstrated that zebra fish cardiac myocytes and vascular smooth muscle expressed functional ATP-sensitive potassium channels channels of similar subunit composition, structure, and metabolic sensitivity to their mammalian counterparts.