muscle cells

[Journal of Cellular and Molecular Medicine] Investigators explored the antipyroptotic effects of long noncoding RNA (lncRNA) FGF9-associated factor (FAF) in acute myocardial infarction.

[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Early vascular aging (EVA) is distinct from chronological ageing, and research is ongoing to identify a definitive molecular signature of EVA. This will facilitate the discovery of new clinical tests for early detection of EVA and identify therapeutic targets to halt (or prevent) EVA in smooth muscle cells, thus reducing macrovascular morbidity and mortality.

[Colloids and Surfaces B-Biointerfaces] Researchers constructed hydrogel substrates with the stiffness of 18–86 kPa to explore the effect of physiological stiffness on vascular cells.

[NPJ Regenerative Medicine] Researchers described a new method of constructing a vascular network in vivo that allowed for the construction of thick human myocardial tissue from multi-layered cell sheets.

[Scientific Reports] The authors investigated whether local delivery of adeno-associated viral (AAV) vectors expressing oxidation-resistant wild type apolipoprotein A1 (apoA1) preserved apoA1 functionality.

[Stem Cell Reports] Scientists performed molecular dynamic simulations to determine the effect of missense variant rs2229774 on retinoic acid receptor gamma (RARG) structure and then validated these predictions using CRISPR-Cas9-genome-edited, induced pluripotent stem cell-derived cardiomyocytes.