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muscle cells

Negative Inotropic Mechanisms of β-Cardiotoxin in Cardiomyocytes by Depression of Myofilament ATPase Activity without Activation of the Classical β-Adrenergic Pathway

[Scientific Reports] The effects of beta-cardiotoxin on isolated cardiac myocyte functions, calcium homeostasis, the phosphorylation level of targeted proteins, and the myofibrillar ATPase activity were studied.

HIF-1α Promotes the Proliferation and Migration of Pulmonary Arterial Smooth Muscle Cells via Activation of Cx43

[Journal of Cellular and Molecular Medicine] The authors suggested that HIF-1α, as an upstream regulator, promoted the expression of Connexin 43 (Cx43), and the HIF-1α/Cx43 axis regulated the proliferation and migration of pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension.

Circular RNA circLIFR Regulates the Proliferation, Migration, Invasion and Apoptosis of Human Vascular Smooth Muscle Cells via the miR-1299/KDR Axis

[Metabolic Brain Disease] Scientists explored the detailed role and mechanism of circRNA LIF receptor subunit alpha in human umbilical artery smooth muscle cells.

Muscle-Specific Programmed Cell Death 5 Deletion Attenuates Cardiac Aging

[International Journal of Cardiology] Researchers revealed that programmed cell death 5 (Pdcd5) deficiency attenuated cardiac aging by reducing cellular senescence and apoptosis, and increasing Parkin-mediated mitophagy, likely through p53.

Cardiac Aorta-Derived Extracellular Matrix Scaffold Enhances Critical Mediators of Angiogenesis in Isoproterenol-Induced Myocardial Infarction Mice

[Journal of Materials Science-Materials in Medicine] The authors investigated whether cardiomyocytes culturing on cardiac aorta-derived extracellular matrix scaffold had advantageous effects on cardiomyocytes survival and angiogenesis biomarkers’ expression.

The Role of Vascular Smooth Muscle Cells in the Development of Aortic Aneurysms and Dissections

[European Journal of Clinical Investigation] The authors summarize current knowledge about vascular smooth muscle cells (vSMCs) functions within the aortic wall and give an overview of how vSMC functions are dysregulated in aortic aneurysms and aortic dissections pathogenesis, organized per anatomical location.

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