muscle cells

[Cell Death Discovery] Investigators established an in vitro model of alcoholic cardiomyopathy based on human induced pluripotent stem cell-derived cardiomyocytes.

[Scientific Reports] To understand the interplay between cardiomyocyte and nonmyocyte cell types in human hypertrophic cardiomyopathy (HCM), single nuclei RNA-sequencing was performed on myectomy specimens from HCM patients with left ventricular outflow tract obstruction and control samples from donor hearts free of cardiovascular disease.

[Ebiomedicine] Sodium thiosulfate, a drug used for the treatment of cyanide poisoning and calciphylaxis, protected against intimal hyperplasia in a mouse model of arterial restenosis and in human vein segments.

[Biochemical and Biophysical Research Communications] Scientists investigated the molecular mechanism by which valproic acid inhibited rat vascular smooth muscle cell proliferation.

[Communications Biology] Researchers showed that KDM3A was significantly downregulated in rat ischemia/reperfusion and cellular hypoxia/reoxygenation models. KDM3A knockout exacerbated cardiac dysfunction and cardiomyocytes injury both in vivo and in vitro.

[Advanced Science] Scientists isolated extracellular vesicles (EVs) from key stages of the human induced pluripotent stem cell-cardiomyocyte differentiation and maturation, with the aim of identifying a promising cell biofactory for EV production, and pinpointed the genetic signatures of bioactive EVs.