The Histone Demthylase KDM3A Protects the Myocardium from Ischemia/Reperfusion Injury via Promotion of ETS1 Expression

Researchers showed that KDM3A was significantly downregulated in rat ischemia/reperfusion and cellular hypoxia/reoxygenation models. KDM3A knockout exacerbated cardiac dysfunction and cardiomyocytes injury both in vivo and in vitro.