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myeloid cells

The Non-ELR CXC Chemokine Encoded by Human Cytomegalovirus UL146 Genotype 5 Contains a C-Terminal β-Hairpin and Induces Neutrophil Migration as a Selective CXCR2 Agonist

[PLoS Pathogens] Researchers investigated how the diversity of UL146 in Human cytomegalovirus affected its signaling and structural properties to understand why its genetic diversity is maintained across human populations.

Bordetella pertussis-Infected Innate Immune Cells Drive the Anti-pertussis Response of Human Airway Epithelium

[Scientific Reports] Researchers investigated the epithelial cell response to B. pertussis infection in primary human airway epithelium differentiated at air–liquid interface.

Astragalus and Human Mesenchymal Stem Cells Promote Wound Healing by Mediating Immunomodulatory Effects through Paracrine Signaling

[Regenerative Medicine] A murine model of a skin wound was treated with a combination of extract of astragalus and exosomes of MSCs. CD11b+ and CD45 macrophages were detected and levels of cytokines were tested.

Nociceptor-Derived Reg3γ Prevents Endotoxic Death by Targeting Kynurenine Pathway in Microglia

[Cell Reports] Scientists identified C-type lectin Reg3γ as a nociceptor-enriched hormone that protected the host from endotoxic death.

Cross-Talk between GABAergic Postsynapse and Microglia Regulate Synapse Loss after Brain Ischemia

[Science Advances] Scientists reported that at 24 hours after ischemia, microglia released brain-derived neurotrophic factor to downregulate glutamatergic and GABAergic synapses within the peri-infarct area.

Microglia Integration into Human Midbrain Organoids Leads to Increased Neuronal Maturation and Functionality

[Glia] Investigators described an approach to derive microglia from human induced pluripotent stem cells (iPSCs) and integrated them into iPSC-derived midbrain organoids.

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