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myeloid cells

Spatial Proteogenomics Reveals Distinct and Evolutionarily Conserved Hepatic Macrophage Niches

[Cell] By integrating multi-omic datasets, investigators provided validated strategies to reliably discriminate and localize all hepatic cells, including a population of lipid-associated macrophages at the bile ducts.

Analysis of the Glyco-Code in Pancreatic Ductal Adenocarcinoma Identifies Glycan-Mediated Immune Regulatory Circuits

[Communications Biology] By analysing publicly available transcriptomic data of patient samples and cell lines, researchers identified here two specific glycan profiles in pancreatic ductal adenocarcinoma that correlated with progression, clinical outcome and epithelial to mesenchymal transition status.

Hyperinflammatory Environment Drives Dysfunctional Myeloid Cell Effector Response to Bacterial Challenge in COVID-19

[PLoS Pathogens] Investigators assessed the influence of COVID-19 plasma hypercytokinemia on the functional responses of myeloid immune cells upon bacterial challenges from acute-phase COVID-19 patients and their corresponding recovery (rec)-phase.

Engineered Clustered Myoblast Cell Injection Augments Angiogenesis and Muscle Regeneration in Peripheral Artery Disease

[Molecular Therapy] Clustered cells from myoblast cell sheets obtained from C57/BL6 mice were administered into ischemic mouse muscles seven days after induction of ischemia.

Three Tissue Resident Macrophage Subsets Coexist across Organs with Conserved Origins and Life Cycles

[Science Immunology] Monocyte-derived macrophages contributed to the resident macrophage population until they reached a defined upper limit after which they did not outcompete pre-existing resident macrophages.

Neuropilin-1, a Myeloid Cell-Specific Protein, Is an Inhibitor of HIV-1 Infectivity

[Proceedings of the National Academy of Sciences of the United States of America] Scientists reported that NRP-1, encoding transmembrane protein neuropilin-1, was highly expressed in macrophages and dendritic cells but not CD4+ T cells, serving as an anti-HIV factor to inhibit the infectivity of HIV-1 progeny virions.

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