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myeloid cells

Systemic and Local Innate Immune Responses to Surgical Co-Transplantation of Mesenchymal Stromal Cells and Biphasic Calcium Phosphate for Bone Regeneration

[Acta Biomaterialia] Scientists assessed the local and systemic innate immune responses to implantation of biphasic calcium phosphate biomaterial alone, or with bone marrow derived MSC, in critical-sized calvarial bone defects of Lewis rats.

Therapeutic IGF-I Receptor Inhibition Alters Fibrocyte Immune Phenotype in Thyroid-Associated Ophthalmopathy

[Proceedings of the National Academy of Sciences of the United States of America] Investigators demonstrated that teprotumumab, an anti-insulin-like growth factor I receptor inhibitor, attenuated constitutive expression and induction by the thyroid-stimulating hormone of MHC II and these B7 members in CD34+ fibrocytes.

A Multivariate Modeling Framework to Quantify Immune Checkpoint Context-Dependent Stimulation on T Cells

[Cell Discovery] Researchers established an experimental system including a stimulus of interest, applied to an immune cell type in several contexts.

TMT-Based Quantitative Proteomic Profiling of Human Monocyte-Derived Macrophages and Foam Cells

[Proteome Science] Human peripheral blood mononuclear cells were stimulated with macrophage colony-stimulating factor, and obtained macrophages were transformed into foam cells by oxidized low-density lipoprotein.

The Dual Role of Neutrophils in Cancer

[Seminars in Immunology] The authors summarize and detail clinical and experimental evidence for, and underlying mechanisms of, the dual impact of neutrophils' functions, both supporting and inhibiting cancer development.

Phase I Study of Anti-CD47 Monoclonal Antibody CC-90002 in Patients with Relapsed/Refractory Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndromes

[Annals of Hematology] In this first clinical, phase I, dose-escalation and -expansion study, scientists evaluated CC-90002 in patients with relapsed/refractory acute myeloid leukemia or high-risk myelodysplastic syndromes.

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