myocardial infarction

[Circulation Research] Cultured neonatal rat ventricular myocytes (NRVMs) were exposed to Tat-Beclin during simulated ischemia/reperfusion injury. ATG7 knockdown by siRNA in NRVMs was used to evaluate the role of autophagy.

[Aging] Researchers cultured human amniotic epithelial cells (hAECs) and extracted exosomes from culture supernatants. They established a stable acute myocardial infarction model in rats and treated them with hAECs, exosomes, or PBS.

[Nature] Investigators presented how the detyrosination of microtubules in cardiomyocytes was finely tuned by microtubule-affinity regulating kinase 4 (MARK4) to regulate cardiac inotropy, and identified MARK4 as a promising therapeutic target for improving cardiac function after myocardial infarction.

[Cell Death & Disease] Adropin in vitro reduced hydrogen peroxide-induced apoptosis in rat bone marrow MSCs and improved MSCs survival with increased phosphorylation of Akt and extracellular regulated protein kinases.

[International Journal of Pharmaceutics] Injectable alginate based microporous hydrogel were used to deliver 5-Azacytidine in zein protein nanoparticle with mesenchymal stem cells for attenuating adverse cardiac remodelling after myocardial infarction.

[Nature Reviews Cardiology] Scientists discuss how the synergy between inflammation and thrombosis drives thrombotic diseases. They focus on the huge potential of anti-inflammatory strategies to target cardiovascular pathologies.