myocardial infarction

[Scientific Reports] The authors identified potential anti-inflammatory effects of P2Y12 receptor blockers on monocytes and macrophages.

[International Journal of Stem Cells] Researchers investigated the potential role of irisin in the angiogenesis of bone-marrow mesenchymal stem cells (BMSCs). In vivo, irisin-treated BMSCs were transplanted into an myocardial infarction mouse model.

[Oxidative Medicine and Cellular Longevity] The authors investigated the effects of silencing salusin-β on endothelial function, cardiac function, vascular and myocardial remodeling, and its underlying signaling pathways in chronic heart failure rats induced by coronary artery ligation.

[Toxicology and Applied Pharmacology] Researchers found that bisphenol A (BPA) exposure altered cardiac function in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Acute BPA exposure in hiPSC-CMs resulted in reduced field potential, as measured by multielectrode array

[Scientific Reports] Scientists screened for targets for the treatment of ischemia–reperfusion injury using a combination of shRNA and drug library analyses in HL-1 mouse cardiomyocytes subjected to hypoxia and reoxygenation.

[NPJ Regenerative Medicine] By multiple in vitro studies, the rhACE2 patch demonstrated effectiveness in reducing cardiomyocytes apoptosis under hypoxia stress and inhibiting cardiac fibroblasts proliferation, which gave evidence for its in vivo efficacy.