myocardium

[Acta Pharmacologica Sinica] Scientists investigated whether asiatic acid exerted cardioprotective effects against myocardial infarction by activating glycophagy and mitophagy to improve the energy balance. In vitro cardioprotective effects were examined in neonatal mouse cardiomyocytes subjected to oxygen-glucose deprivation for 12 hours.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists directly assessed the frequency of DNA damage of the murine myocardium during natural aging and in hearts from four mouse models of premature aging.

[Cell Research] Research demonstrated that atrial cardiomyocytes have an intrinsic glutamatergic transmitter system, which regulated the generation and propagation of action potentials.

[Nature Cell Biology] Scientists showed that, in late fetal development, the embryonic coronary plexus at the inner myocardium of the ventricles expressed the angiogenic signaling factors VEGFR3 and DLL4 and generates new coronary vessels in neonates.

[FASEB Journal] To simulate type 2 diabetes-associated metabolic and inflammatory status in an ex vivo tissue culture model, human epicardial adipose tissue (EAT) samples were treated with a cocktail composed of high glucose, high palmitate, and lipopolysaccharide and were compared with control EAT.

[Cell Death & Disease] Researchers found that a dietary saturated fatty acid, palmitate increased intracellular cAMP synthesis through the palmitoylation of soluble adenylyl cyclase in cardiomyocytes.