Potential Role of Epicardial Adipose Tissue in Coronary Artery Endothelial Cell Dysfunction in Type 2 Diabetes

To simulate type 2 diabetes-associated metabolic and inflammatory status in an ex vivo tissue culture model, human epicardial adipose tissue (EAT) samples were treated with a cocktail composed of high glucose, high palmitate, and lipopolysaccharide and were compared with control EAT.