myocardium

[Circulation Research] Cultured neonatal rat ventricular myocytes (NRVMs) were exposed to Tat-Beclin during simulated ischemia/reperfusion injury. ATG7 knockdown by siRNA in NRVMs was used to evaluate the role of autophagy.

[Heartseed, Inc.] Heartseed Inc. and Novo Nordisk A/S announced that they have entered into a collaboration and licence agreement for the development, manufacturing and commercialisation of Heartseed’s asset HS-001, an investigational cell therapy using purified cardiomyocytes derived from induced pluripotent stem cells, which is currently under development by Heartseed for the treatment of heart failure.

[ACS Nano] Researchers examined whether pathogenic mutations perturbed the nanomechanics of cardiac myosin-binding protein C, which would compromise its modulatory mechanical tethers across sliding actomyosin filaments.

[Scientific Reports] Scientists identified cell–cell and cell-ECM interactions in the microenvironment of the early four-chambered vertebrate heart that drive cardiomyocyte organization and alignment.

[npj Aging and Mechanisms of Disease] Researchers showed that the transverse tubular system (t-system) and proteins underlying excitation-contraction coupling in cardiomyocytes are characteristically remodeled with age, characterized by t-system alterations and sarcolemmal dissociation of ryanodine receptor clusters.

[Nature Communications] Scientists developed the selective anti-Transthyretin amyloid antibody NI301A, a recombinant human monoclonal immunoglobulin G1.