Natural Killer Cells

[Frontiers in Immunology] Scientists showed that polymorphonuclear-myeloid-derived suppressor cells were present in high numbers in the polymorphonuclear of patients with primary or metastatic lung tumor.

[Trends in Molecular Medicine] Natural killer (NK) cells lend themselves to off-the-shelf applications owing to their favorable safety profile and retained efficacy in an allogeneic setting.

[Clinical Cancer Research] Researchers used mass cytometry by time-of-flight, flow cytometry, and T cell receptor immunosequencing to conduct simultaneous single-cell analyses of immune cells in the sentinel lymph nodes of melanoma patients.

[Genome Biology] Four clocks resulted in similar predictions of individual chronological age, and their constituting CpGs were correlated in DNA methylation level and were enriched for similar histone modifications and chromatin states.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists reported an additional but previously unknown role of PDGF-D, whereby it mediated interleukin-15–induced human NK cell survival but not effector functions via its binding to PDGFRβ but independent of its binding to NKp44.

[Fate Therapeutics, Inc.] Fate Therapeutics, Inc. announced that the US FDA has cleared the company’s Investigational New Drug application for FT536, an off-the-shelf, multiplexed-engineered, iPSC-derived, chimeric antigen receptor NK cell product candidate.