Natural Killer Cells

[Critical Reviews in Oncology/Hematology] Investigators introduce the mechanism of platelet-related tumor metastasis and particularly focus on the role of cell adhesion molecules in it.

[Scientific Reports] Intraperitoneal injection of lipopolysaccharide and oral gavage of ampicillin increased IFN-γ and TNF-α expression in the spleen, colon, and hippocampus, while IL-10 expression decreased.

[Oncogene] To identify clinically relevant microenvironmental and cancer features, scientists applied single-cell RNA sequencing to ten human lung adenocarcinomas and ten normal control tissues.

[Molecular Therapy-Oncolytics] CAR-engineered natural killer (NK)-92 cells have demonstrated robust antitumor activity in in vitro and in vivo preclinical studies, propelling the clinical development of CAR NK-92 cells.

[Gates Biomanufacturing Facility] The Gates Biomanufacturing Facility signed a continued strategic agreement with Nkarta to manufacture clinical supply of therapeutic Natural Killer cells. As part of this collaboration, GBF will continue to manufacture NKX101, an immunotherapy currently in a Phase I clinical trial for patients with relapsed/refractory acute myeloid leukemia or higher-risk myelodysplastic syndromes.

[Journal of Cell Communication and Signaling] The authors explain the basic mechanisms for the interactions and communications between immunosuppressive, anti-tumoral, and cancer cells within the tumor microenvironment (TME), and discuss the modulating effects of metformin on various cells and secretions in the TME.