Natural Killer Cells

[Cell Stem Cell] Natural killer (NK) cells derived from uniformly engineered iPSCs, termed iADAPT, displayed metabolic features and gene expression profiles mirroring those of cytomegalovirus-induced adaptive NK cells.

[Clinical Cancer Research] Investigators combined radiation, immunotherapies, genetic mouse models, and antibody depletion experiments to identify the role of NK cells in overcoming resistance to radiation therapy in orthotopic models of head and neck squamous cell carcinoma

[Science Advances] The authors reported that high-salt diet induces natural killer cell–mediated tumor immunity by inhibiting PD-1 expression while enhancing IFNγ and serum hippurate.

[Hepatology] Investigators found high expression of RORα in liver-resident NK cells/ILC1s. Mice with conditional ablation of Rora in LrNK cells/ILC1s and conventional NK (cNK) cells had decreased LrNK cells/ILC1s but normal numbers of cNK cells.

[Scientific Reports] Investigators analyzed expression of DNAM-1 in leukemic cells of AML patients. Interaction of DNAM-1 with its ligands CD112 and CD155 induced release of the immunomodulatory cytokines IL-6, IL-8 IL-10 and TNF-α by AML cells and DNAM-1 expression correlated with a more differentiated phenotype.

[Cell Death & Disease] Investigators found that pharmacologic inhibition of neddylation using a small-molecule inhibitor, MLN4924/Pevonedistat, increased the expression of the natural killer (NK) cell-activating receptor NKG2D ligands MICA and MICB on the plasma membrane of different multiple myeloma cell lines and patient-derived plasma cells, leading to enhanced NK cell degranulation.