neural cells

[Cell Death & Disease] we investigated the effects of neuron-specific Dynamin-related protein 1 deletion on synaptic damage and mitophagy in the hippocampus of a high-fat diet (HFD)/streptozotocin (STZ)-induced diabetic mice.

[Nmr in Biomedicine] Dynamic nuclear polarization‐magnetic resonance imaging chemical shift imaging with hyperpolarized [1‐13C] pyruvate was conducted to evaluate the metabolic change in glycolytic profiles after radiation of two glioma stem‐like cell‐derived gliomas and an adherent human glioblastoma cell line in an orthotopic xenograft mouse model.

[Journal of Clinical Investigation] Scientists performed histological assays and unbiased single-cell RNA sequencing analysis on cerebral organoids derived from four euploid cell lines and from iPSCs to explore cell type-specific abnormalities associated with Down syndrome during early brain development.

[Proceedings of the National Academy of Sciences of the United States of America] we demonstrated that Patch-seq technology can be applied both to better understand molecular mechanisms underlying a complex neurological disease at the single-cell level and to provide a platform for screening for therapeutics for the disease.

[Proceedings of the National Academy of Sciences of the United States of America] we show that in mouse hippocampal neurons, dense core vesicles fusion is strongly and equally reduced in synaptotagmin-1 (Syt1)- or Syt7-deficient neurons, but combined Syt1/Syt7 deficiency did not reduce fusion further.

[Science Advances] we show that optogenetic activation of parvalbumin-positive cells in the medial septal area enabled selective pacing of local field potential oscillations in medial entorhinal cortex.