neural cells

[Science Advances] Scientists demonstrated that in human neural stem cells, lysosomes are asymmetrically inherited during mitosis.

[Scientific Reports] Researchers developed an artificial intelligence capable of predicting the seizure liability of drugs and identifying drugs using deep learning based on raster plots of neural network activity.

[Nature Communications] Investigators showed that Human Enterovirus A71 (HEVA71)-infected astrocytes released CXCL1 which supported viral replication in neurons by activating the CXCR2 receptor-associated ERK1/2 signaling pathway.

[npj Parkinsons Disease] The authors applied high content imaging on induced pluripotent stem cell-derived neurons from patients with familial Parkinson’s disease bearing the G209A α-synuclein mutation and launched a screening campaign on a small kinase inhibitor library.

[Nature Reviews Drug Discovery] The authors highlight general mechanisms of astrocyte regulation and their potential as therapeutic targets, including drugs that alter astrocyte metabolism, and therapies that target transporters and receptors on astrocytes.

[Journal of Clinical Investigation] Scientists interrogated the role of adenosine-to-Inosine RNA editing mediated by ADAR1 in glioblastoma stem cells and found that both ADAR1 and global RNA editomes were elevated in GSCs compared to normal neural stem cells (NSCs).