neural cells

[Journal of Nanobiotechnology] Effects of CD73+ human umbilical cord MSC-EVs on hydrolyzing ATP into adenosine were detected. The polarization of M2/M1 was verified by immunofluorescence.

[Journal of Nanobiotechnology] Scientists constructed CD73 modified extracellular vesicles and explored the anti-inflammatory effects after spinal cord injury. CD73 engineered extracellular vesicles were derived from human umbilical cord MSCs transduced by lentiviral vectors to upregulate the expression of CD73.

[Scientific Reports] Scientists presented a transgenic, TAR DNA-binding protein-43 (TDP-43)-A315T, mouse model expressing an Amyotrophic Lateral Sclerosis (ALS) phenotype and demonstrated the presence of ubiquitinated cytoplasmic TDP-43 aggregates with > 80% cell death by 28 days post differentiation in vitro.

[Scientific Reports] Researchers presented a transgenic, TDP-43-A315T, mouse model expressing an amyotrophic lateral sclerosis phenotype and demonstrate the presence of ubiquitinated cytoplasmic TDP-43 aggregates with > 80% cell death by 28 days post differentiation in vitro.

[Cell Reports] The authors dissected the genetic and functional heterogeneity of human glioblastoma stem cells within patients by their innate responses to non-pathogenic mouse parvoviruses that were tightly restrained by cellular physiology.

[Nature Communications] Scientists showed that preformed α-syn fibrils increased the association between TLR2 and MyD88, resulting in microglial activation.