neural cells

[Neuron] An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from regenerating in the adult central nervous system. Here scientists show how the two aspects are interwoven.

[Cell Research] Research demonstrated that atrial cardiomyocytes have an intrinsic glutamatergic transmitter system, which regulated the generation and propagation of action potentials.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists reported that levels of nicotinamide adenine dinucleotide (NAD)+ were reduced and markers of inflammation increased in the brains of APP/PS1 mutant transgenic mice with beta-amyloid pathology.

[Archives of Toxicology] Researchers presented the generation and application of a fluorescent human iPSC reporter line for heme oxygenase-1, which is considered a sensitive and reliable biomarker for the oxidative stress response.

[Molecular Psychiatry] The authors discuss how deficits in neurodevelopmental processes may lead to abnormal brain connectivity and how iPSC-based models can be used to identify abnormal connections and to gain insights into underlying cellular and molecular mechanisms to develop novel therapeutics.

[Cell Reports] Investigators showed that patient-derived glioma-stem cells recruited elevated levels of proteins that ensure the temporal cilium disassembly, leading to suppressed ciliogenesis.