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neural cells

NGN2 Induces Diverse Neuron Types from Human Pluripotency

[Stem Cell Reports] Investigators used single-cell transcriptomics to dissect the cell states that emerge during NGN2 overexpression across a time course from pluripotency to neuron functional maturation.

Dynamic Integration of Enteric Neural Stem Cells in Ex Vivo Organotypic Colon Cultures

[Scientific Reports] Scientists examined enteric neural stem cells integration using an adapted ex vivo organotypic culture system. Significant remodelling of the intestinal extracellular matrix and musculature occurred upon transplantation, to facilitate donor cell integration within endogenous enteric ganglia.

Identification of Pimavanserin Tartrate as a Potent Ca2+-Calcineurin-NFAT Pathway Inhibitor for Glioblastoma Therapy

[Acta Pharmacologica Sinica] Researchers carried out research to discover a novel alternative drug targeting the oncogenic NFAT signaling pathway for Glioblastoma multiforme therapy.

Human Sensorimotor Organoids Derived from Healthy and Amyotrophic Lateral Sclerosis Stem Cells Form Neuromuscular Junctions

[Nature Communications] Investigators generated sensorimotor organoids containing physiologically functional neuromuscular junctions and applied the model to different subgroups of amyotrophic lateral sclerosis.

Human Sensorimotor Organoids Derived from Healthy and Amyotrophic Lateral Sclerosis Stem Cells Form Neuromuscular Junctions

[Nature Communications] Investigators generated sensorimotor organoids containing physiologically functional neuromuscular junctions and applied the model to different subgroups of amyotrophic lateral sclerosis.

O-GlcNAc Transferase Ogt Regulates Embryonic Neuronal Development through Modulating Wnt/β-Catenin Signaling

[Human Molecular Genetics] Scientists showed that Ogt was highly expressed in embryonic brain, and Ogt depletion reduced the proliferation of embryonic neural stem cells and migration of new born neurons.

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