Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsScientists showed that Ogt was highly expressed in embryonic brain, and Ogt depletion reduced the proliferation of embryonic neural stem cells and migration of new born neurons.
[Human Molecular Genetics]
6445212 726NSBNH items 1 apa 0 default asc 1 165383 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-a24b3b0c8cdfe41576f74b7fc22cae8e%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22726NSBNH%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Shen%20et%20al.%22%2C%22parsedDate%22%3A%222021-08-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EShen%2C%20H.%2C%20Zhao%2C%20X.%2C%20Chen%2C%20J.%2C%20Qu%2C%20W.%2C%20Huang%2C%20X.%2C%20Wang%2C%20M.%2C%20Shao%2C%20Z.%2C%20Shu%2C%20Q.%2C%20%26amp%3B%20Li%2C%20X.%20%282021%29.%20O-GlcNAc%20transferase%20Ogt%20regulates%20embryonic%20neuronal%20development%20through%20modulating%20Wnt%5C%2F%26%23x3B2%3B-catenin%20signaling.%20%3Ci%3EHuman%20Molecular%20Genetics%3C%5C%2Fi%3E%2C%20%3Ci%3Eddab223%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fhmg%5C%2Fddab223%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fhmg%5C%2Fddab223%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3D726NSBNH%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22O-GlcNAc%20transferase%20Ogt%20regulates%20embryonic%20neuronal%20development%20through%20modulating%20Wnt%5C%2F%5Cu03b2-catenin%20signaling%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hui%22%2C%22lastName%22%3A%22Shen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xingsen%22%2C%22lastName%22%3A%22Zhao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junchen%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wenzheng%22%2C%22lastName%22%3A%22Qu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoli%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mengxuan%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zhiyong%22%2C%22lastName%22%3A%22Shao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiang%22%2C%22lastName%22%3A%22Shu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xuekun%22%2C%22lastName%22%3A%22Li%22%7D%5D%2C%22abstractNote%22%3A%22Ogt-mediated%20O-GlcNAcylation%20is%20enriched%20in%20the%20nervous%20system%2C%20and%20involves%20in%20neuronal%20development%2C%20brain%20function%20and%20neurological%20diseases.%20However%2C%20the%20roles%20of%20Ogt%20and%20O-GlcNAcylation%20in%20embryonic%20neurogenesis%20has%20remained%20largely%20unknown.%20Here%2C%20we%20show%20that%20Ogt%20is%20highly%20expressed%20in%20embryonic%20brain%2C%20and%20Ogt%20depletion%20reduces%20the%20proliferation%20of%20embryonic%20neural%20stem%20cells%20and%20migration%20of%20new%20born%20neurons.%20Furthermore%2C%20Ogt%20in%20cultured%20hippocampal%20neurons%20impaires%20neuronal%20maturation%20including%20reduced%20dendritic%20numbers%20and%20length%2C%20and%20immature%20development%20of%20spines.%20Mechanistically%2C%20Ogt%20depletion%20decreases%20the%20activity%20of%20Wnt%5C%2F%5Cu03b2-catenin%20signaling.%20Ectopic%20%5Cu03b2-catenin%20rescues%20neuronal%20developmental%20deficits%20caused%20by%20Ogt%20depletion.%20Ogt%20also%20regulates%20human%20cortical%20neurogenesis%20in%20forebrain%20organoids%20derived%20from%20induced%20pluripotent%20stem%20cells.%20Our%20findings%20reveal%20the%20essential%20roles%20and%20mechanisms%20of%20Ogt-mediated%20O-GlcNAc%20modification%20in%20regulating%20mammalian%20neuronal%20development.%22%2C%22date%22%3A%22August%204%2C%202021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fhmg%5C%2Fddab223%22%2C%22ISSN%22%3A%220964-6906%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fhmg%5C%2Fddab223%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-08-05T16%3A36%3A42Z%22%7D%7D%5D%7D
Shen, H., Zhao, X., Chen, J., Qu, W., Huang, X., Wang, M., Shao, Z., Shu, Q., & Li, X. (2021). O-GlcNAc transferase Ogt regulates embryonic neuronal development through modulating Wnt/β-catenin signaling. Human Molecular Genetics, ddab223. https://doi.org/10.1093/hmg/ddab223 Cite
