A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury

Scientists showed that notch signaling-deficient astrocytes could generate new neurons after injury. Using single-cell RNA sequencing, they found that, when notch signaling was blocked, astrocytes transitioned to a neural stem cell-like state.
[Cell Stem Cell]
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Activation of a Neural Stem Cell Transcriptional Program in Parenchymal Astrocytes

Researchers used single-cell RNA sequencing to characterize neurogenesis by notch-depleted striatal astrocytes in vivo.
[eLife]
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Diversity and Function of Corticopetal and Corticofugal GABAergic Projection Neurons

Research conducted over the past 10 years has revealed that cortical GABAergic projection neurons are highly diverse in terms of molecular marker expression, synaptic targeting, activity pattern during distinct behavioural states and precise temporal recruitment relative to ongoing neuronal network oscillations.
[Nature Reviews Neuroscience]
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Interplay between V-ATPase G1 and Small EV-miRNAs Modulates ERK1/2 Activation in GBM Stem Cells and Non-Neoplastic Milieu

The authors investigated the role of V1G1 in glioma stem cell small extracellular vesicles and their effects on primary brain cultures.
[Molecular Cancer Research]
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Single-Cell Transcriptomics Reveals Multiple Neuronal Cell Types in Human Midbrain-Specific Organoids

Investigators demonstrated that human midbrain organoids showed essential neuronal functional properties as spontaneous electrophysiological activity of different neuronal subtypes, including dopaminergic, GABAergic, glutamatergic and serotonergic neurons.
[Cell and Tissue Research]
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Fabrication of Homotypic Neural Ribbons as a Multiplex Platform Optimized for Spinal Cord Delivery

Neural ribbons offer multifunctionality in vitro including co-encapsulation of the injury site ESM modifier chondroitinase ABC, tested in glial scar models, and ability of cervically-patterned spinal cord neural stem cells to differentiate within neural ribbons and project axons for integration with 3D external matrices.
[Scientific Reports]
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Intrathecal Administration of the Extracellular Vesicles Derived from Human Wharton’s Jelly Stem Cells Inhibit Inflammation and Attenuate the Activity of Inflammasome Complexes after Spinal Cord Injury in Rats

Scientists investigated immunomodulatory potential of human Wharton’s jelly mesenchymal stem cells derived extracellular vesicles on inflammasome activity one week after spinal cord injury in rats.
[Neuroscience Research]
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Developmental GABA Polarity Switch and Neuronal Plasticity in Bioengineered Neuronal Organoids

The authors report the directed self-organization of human induced pluripotent stem cells in a collagen hydrogel towards a highly interconnected neuronal network at a macroscale tissue format.
[Nature Communications]
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Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon

The authors described a robust genetic program that intrinsically attenuated apoptosis competence in neurons.
[Neuron]
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Mithramycin Selectively Attenuates DNA-Damage-Induced Neuronal Cell Death

The authors suggested that Sp1 was required for p53-mediated transactivation of neuronal pro-apoptotic molecules and that mithramycin might have attenuated neuronal cell death in conditions predominantly involving DNA-damage-induced p53-dependent intrinsic apoptosis.
[Cell Death & Disease]
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Modulating Electrophysiology of Motor Neural Networks via Optogenetic Stimulation during Neurogenesis and Synaptogenesis

Researchers used channelrhodopsin-2 transfected mouse ESC-derived motor neurons to explore short and long-term programming of neural networks by using optical stimulation implemented during neurogenesis and synaptogenesis.
[Scientific Reports]
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