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neural cells

FMR1/circCHAF1A/miR-211-5p/HOXC8 Feedback Loop Regulates Proliferation and Tumorigenesis via MDM2-Dependent p53 Signaling in GSCs

[Oncogene] The novel feedback loop among FMR1, circRNA-CHAF1A (circCHAF1A), miR-211-5p, and HOXC8 in glioma stem cells (GSCs) could facilitate the proliferation and tumorigenesis of glioma and GSCs

Nociceptive Sensory Neurons Promote CD8 T Cell Responses to HSV-1 Infection

[Nature Communications] Researchers show that Nav1.8+ sensory neurons, which are involved in pain perception, control the magnitude of CD8 T cell priming and expansion in HSV-1-infected mice.

Nuclear Isoform of FGF13 Regulates Post-Natal Neurogenesis in the Hippocampus through an Epigenomic Mechanism

[Cell Reports] Scientist found that FGF13A, the nuclear isoform of FGF13, is involved in the maintenance of neural stem cells and the suppression of neuronal differentiation during post-natal hippocampal development.

Leptin Increases GABAergic Synaptogenesis through the Rho Guanine Exchange Factor β-PIX in Developing Hippocampal Neurons

[Science Signaling] Using molecular and electrophysiological techniques, researchers found that leptin increased the surface localization of GABAA receptors and the number of functional GABAergic synapses in hippocampal cultures from male and female rat pups.

Novel Fragile X Syndrome 2D and 3D Brain Models Based on Human Isogenic FMRP-KO iPSCs

[Cell Death & Disease] Scientists generated 2D and 3D in vitro human FXS model systems based on isogenic fragile X mental retardation protein knock-out mutant and wild-type human induced pluripotent stem cell (hiPSC) lines.

β-Arrestin 2 Stimulates Degradation of HIF-1α and Modulates Tumor Progression of Glioblastoma

[Cell Death & Disease] Investigators demonstrated that Arrb2 interacted with HIF-1α and stimulated ubiquitin-mediated 26S proteasomal degradation of HIF-1α by recruiting PHD2 and pVHL.

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