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neurons

Cerebral Dopamine Neurotrophic Factor Protects and Repairs Dopamine Neurons by Novel Mechanism

[Molecular Psychiatry] Scientists focus on cerebral dopamine neurotrophic factor (CDNF), an unconventional neurotrophic protein. CDNF delivered to the brain parenchyma protects and restores dopamine neurons in animal models of Parkinson’s disease.

Novel Chemical Inhibitor against SOD1 Misfolding and Aggregation Protects Neuron-Loss and Ameliorates Disease Symptoms in ALS Mouse Model

[Communications Biology] Using ELISA-based chemical screening with wild and mutant superoxide dismutase (SOD1) proteins, the authors screened a new small molecule, PRG-A01, which could block the misfolding/aggregation of SOD1 or TDP-43. The drug rescued the cell death induced by mutant SOD1 in human neuroblastoma cell line.

Chemical Approach to Generating Long-Term Self-Renewing pMN Progenitors from Human Embryonic Stem Cells

[Journal of Molecular Cell Biology] Based on the chemical screening, the authors developed a new recipe for efficient induction of progenitors of motor neurons progenitors from human embryonic stem cells.

Bidirectional Cell-Matrix Interaction Dictates Neuronal Network Formation in a Brain-Mimetic 3D Scaffold

[Acta Biomaterialia] The authors bioengineered a physiologically relevant 3D scaffold by integrating brain-like extracellular matrix components and chemical cues.

Neurocognitive and Hypokinetic Movement Disorder with Features of Parkinsonism after BCMA-Targeting CAR-T Cell Therapy

[Nature Medicine] Public transcriptomic datasets confirmed B cell maturation antigen (BCMA) RNA expression in the caudate of normal human brains, suggesting that this may be an on-target effect of anti-BCMA therapy.

Engineering Stress in Thin Films: An Innovative Pathway Toward 3D Micro and Nanosystems

[Small] Transformation of conventional 2D platforms into unusual 3D configurations provides exciting opportunities for sensors, electronics, optical devices, and biological systems.

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