neurons

[Cell Death Discovery] Scientists reported that atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide accelerated the dopaminergic differentiation of human induced pluripotent stem cells (hiPSCs)-derived neural population, making these attractive molecules for both neuroprotection and neurorepair in Parkinson’s disease (PD).

[Nature Reviews Neuroscience] The authors present a combined neural network for environmental stress responses, providing insights into the central circuit mechanism for the integrative regulation of systemic organs.

[Science Translational Medicine] Scientists demonstrated that targeted small-molecule degradation of an expanded G4C2 RNA repeat [r(G4C2)exp] was a strategy for mitigating amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD)-associated pathologies and studying disease-associated pathways in preclinical models.

[Cell Stem Cell] Scientists defined the regulation of enteric glial cells heterogeneity in homeostasis and chronic inflammatory bowel disease.

[American Journal of Psychiatry] An in vitro model of fetal human brain development, induced human iPSC–derived cerebral organoids, were used to test whether cerebral organoids were suitable for studying the impact of prenatal glucocorticoid exposure on the developing brain.

[Cell Death & Disease] Scientists applied unpredictable stress stimuli to breast tumor-bearing mice and established a xenograft model of breast cancer that suffered mental stress. This was followed by behavioral tests, tumor growth tracking, immune analysis, miRNA screening, and tumor cell proliferation analysis.