neurons

[iScience] Scientists investigated DNA, RNA, epigenetics, and proteins in iPSC-derived motor neurons from patients with amyotrophic lateral sclerosis (ALS) carrying hexanucleotide expansions in C9ORF72.

[Communications Biology] The authors examined the vertical-mixing effect on brain organoid structures using bioreactors and established inverted brain organoids.

[Translational Psychiatry] Researchers generated iPSCs from patients with familial schizophrenia, differentiated these cells into neurons, and investigated the molecular and cellular phenotypes of the patient’s neurons.

[Stem Cell Reviews and Reports] Scientists differentiated human amniotic fluid-derived iPSCs into a mixed population of neurons. Functional assessments were performed by evaluating electrophysiological properties and the effect of a panel of neuropharmacological agents on spontaneous activity.

[Nature Neuroscience] Researchers reported the development of a cerebral organoid slice model derived from human induced pluripotent stem cells that recapitulated mature cortical architecture and displayed early molecular pathology of C9ORF72 ALS/FTD.

[Cell Death Discovery] With various stimulus, chances for neural stem cells (NSCs) to differentiate into neurons, astrocytes, oligodendrocytes are great and is considered as a potential source of the stem cell therapy to SCI. Scientists used adeno-associated virus to carry the target gene to transfect NSCs.