neurons

[Neuropsychopharmacology] An understanding of the development and evolution of the PFC provide insight into the pathogenesis and treatment of congenital neuropsychiatric diseases as well as idiopathic developmental disorders that cause intellectual disabilities.

[The Hereditary Neuropathy Foundation] The Hereditary Neuropathy Foundation (HNF), in partnership with Rarebase, is leading the charge in the first-ever research initiative to tackle multiple types of CMT in one project, with a primary goal to test candidate drugs in patient-derived cellular models, specifically; iPSC-derived neurons.

[Science Advances] The authors designed PEGylated lipid nanoparticles loaded with a non-opioid analgesic, bupivacaine, to target neurons within breast cancer tumors and suppress nerve-to-cancer cross-talk.

[Nature Communications] Researchers showed that Acly expression was reduced upon loss of Elongator activity, further connecting Elongator to Atat1 in a pathway regulating α-tubulin acetylation and MT-dependent transport in projection neurons, across species.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists combined glial chemogenetics with genetically encoded calcium indicators expressed in enteric neurons and glia to study network-level activity in the intact myenteric plexus of the proximal colon.

[Scientific Reports] Renshaw cells (RCs) are one of the most studied spinal interneurons; however, their roles in motor control remain enigmatic in part due to the lack of experimental models to interfere with RC function, specifically in adults. Scientists leveraged the distinct temporal regulation of Calbindin expression in RCs to create genetic models for timed RC manipulation.