neurons

[Cell Research] Research demonstrated that atrial cardiomyocytes have an intrinsic glutamatergic transmitter system, which regulated the generation and propagation of action potentials.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists reported that levels of nicotinamide adenine dinucleotide (NAD)+ were reduced and markers of inflammation increased in the brains of APP/PS1 mutant transgenic mice with beta-amyloid pathology.

[Archives of Toxicology] Researchers presented the generation and application of a fluorescent human iPSC reporter line for heme oxygenase-1, which is considered a sensitive and reliable biomarker for the oxidative stress response.

[Molecular Psychiatry] The authors discuss how deficits in neurodevelopmental processes may lead to abnormal brain connectivity and how iPSC-based models can be used to identify abnormal connections and to gain insights into underlying cellular and molecular mechanisms to develop novel therapeutics.

[National Institutes of Health] The National Institutes of Health is awarding seven projects a total of $18.15 million over five years to a new effort focused on interoception — the ways in which organisms sense and regulate signals within their bodies. One project will investigate the functional identification of vagal sensory neurons innervating the liver.

[Nature Communications] Investigators generated a induced pluripotent stem cell Alzheimer's disease model using human derived cells, which showed signs of Aβ plaques, dystrophic neurites around plaques, synapse loss, dendrite retraction, axon fragmentation, phospho-Tau induction, and neuronal cell death in one model.