neurons

[Molecular Psychiatry] Researchers generated cortical organoids from skin fibroblasts of patients with 16p11.2 copy number varient to investigate impacted neurodevelopmental processes and showed that organoid size recapitulated macrocephaly and microcephaly phenotypes observed in the patients with 16p11.2 deletions and duplications.

[Chembiochem] Scientists demonstrated that genomic integration of expression cassettes for a pyrrolysyl-tRNA synthetase, pyrrolysyl-tRNA and the target protein of interest enables site-specific incorporation of a non-canonical amino acid in response to amber stop codons.

[Frontiers in Cell and Developmental Biology] Research developed a simple method to generate homogeneous immature oligodendrocyte lineage cells from mouse embryonic stem cells-derived neural stem cell.

[iScience] Reserachers reported that sustained activation of GluK2 subunit-containing Kainate receptors leads to AMPA receptor endocytosis and induce long-term depression of AMPARs in hippocampal neurons.

[Scientific Reports] Scientists used iPSCs from a patient carrying a p.A152T tau variant to create a robust, functional cellular assay system for probing pathophysiological tau accumulation and phosphorylation.

[Scientific Reports] The authors demonstrated co-localization of CTCF with Polycomb-repressed chromatin marked by H3K27me3 in pluripotent cells, progressively decreasing in neural precursor cells and differentiated neurons.