Cortical Organoids Model Early Brain Development Disrupted by 16p11.2 Copy Number Variants in Autism

Researchers generated cortical organoids from skin fibroblasts of patients with 16p11.2 copy number varient to investigate impacted neurodevelopmental processes and showed that organoid size recapitulated macrocephaly and microcephaly phenotypes observed in the patients with 16p11.2 deletions and duplications.