neutrophils

[European Journal of Haematology] Scientists analyzed the outcomes of 483 patients who received hematopoietic stem cell transplantation between August 2017 and August 2020 in a retrospective study, comparing the outcomes between those who received cryopreserved or fresh peripheral blood stem cell grafts.

[Scientific Reports] Researchers investigated the significance of sPD-L1 in cancer patients receiving immune checkpoint inhibitor therapy.

[Nature Communications] Using single-cell RNA sequencing of immune cells from renal clear cell carcinoma patients, investigators identified two distinct transcriptional fates for tumor-infiltrating Treg cells, Fate-1 and Fate-2.

[X4 Pharmaceuticals, Inc.] X4 Pharmaceuticals, Inc. announced that it has completed enrollment in the ongoing pivotal Phase II clinical trial of its lead candidate, mavorixafor, in the treatment of patients with genetically confirmed warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene.

[iScience] Scientists showed that RSV-induced alveolar macrophages, which produced high levels of matrix metalloproteinase-12, exacerbated allergic airway inflammation with increased neutrophil infiltration.

[Science Advances] The authors showed that the efficacy of immune-stimulatory gene therapy was enhanced in isocitrate-dehydrogenase 1 (mIDH1) gliomas, due to the reprogramming of the myeloid cells’ compartment infiltrating the tumor microenvironment.