neutrophils

[Scientific Reports] Researchers separated chicken bone marrow-derived mesenchymal stem cells (BM-MSCs); investigated whether BM-MSCs could improve lipopolysaccharide-induced lung and distal organ injury; and explored the underlying mechanisms.

[Cell Metabolism] Mechanistically, the authors found that grancalcin binds to the plexin-b2 receptor and partially inactivated its downstream signaling pathways, thus repressing osteogenesis and promoting adipogenesis of bone marrow mesenchymal stromal cells.

[Scientific Reports] Plasma markers of neutrophil extracellular traps formation were elevated in liver cirrhosis and correlated to the degree of liver dysfunction in patients with liver cirrhosis and/or hepatocellular carcinoma.

[JCI Insight] Scientists demonstrated that collagen-induced DDR1 activation in cancer cells was a major stimulus for CXCL5 production, resulting in the recruitment of tumor-associated neutrophils, the formation of neutrophil extracellular traps, and subsequent cancer cell invasion and metastasis.

[Clinical and Experimental Pharmacology and Physiology] Investigators investigated the involvement of GRB2-associated binding protein 1 (GAB1) in septic lung injury. Lipopolysaccharide induced mouse model and A549 cell model were used to similar the septic lung injury.

[Mucosal Immunology] Researchers generated dendritic cell-specific Ripk1−/− mice in a genetic background with loss of RIPK1 kinase activity and found that the mice developed spontaneous colonic inflammation characterized by increased neutrophil and Ly6C+ monocytes.