NF-κB

[Free Radical Biology and Medicine] Investigators characterized how Prototheca bovis induced inflammatory responses in mouse mammary gland tissue and mammary epithelial cells.

[Molecular Cancer Research] A transgenic mouse model expressing human Caspase-9b in the lung pneumocytes developed inflammatory lung lesions, which correlated with enhanced activation of the NF-κB pathway and increased influx of immunosuppressive MDSCs in contrast to wild-type mice.

[Nature Communications] Scientists used a “two cell type” whole genome CRISPR-Cas9 screening system to discover key regulators of tumor sensitivity and resistance to natural killer cell-mediated cytotoxicity in human glioblastoma stem cells.

[Nature Cardiovascular Research] Investigators characterized vascular aberrancies induced by myocardial infarction (MI) and proposed to target acquired endothelial cell changes to normalize vessels and promote cardiac repair after MI.

[Cell Reports] Researchers identified five Clostridium strains that suppressed immune-mediated NF-κB activation in epithelial cell lines, peripheral blood mononuclear cells, and gut epithelial organoids from healthy human subjects and patients with inflammatory bowel disease.

[Cell Reports] Researchers identified five Clostridium strains that suppressed immune-mediated NF-κB activation in epithelial cell lines, peripheral blood mononuclear cells, and gut epithelial organoids from healthy human subjects and patients with inflammatory bowel disease.