NF-κB

[Cell Reports] The authors revealed that deoxythymidylate kinase (DTYMK) levels significantly increased and correlated with poor prognosis in hepatocellular carcinoma (HCC).

[Oxidative Medicine and Cellular Longevity] Scientists showed that UVB provoked apoptosis-associated speck-like protein (ASC) speck formation in human primary keratinocytes prior to cell death, and that specks were, opposed to the perinuclear cytosolic localization in myeloid cells, formed in the nucleus.

[Scientific Reports] The authors revealed the important role of insulin gene enhancer-binding protein 1 (ISL1) in androgen receptor (AR)-dependent prostate cancer cell growth; ISL1 knockdown reduced the AR activity and cell growth.

[Scientific Reports] Scientists utilized cromolyn, a mast cell inhibitor with anti-inflammatory capabilities, and its fluorinated analogue F-cromolyn to study fibrosis-related protein regulation and secretion downstream of neuroinflammation and their ability to promote microglial phagocytosis and neurite outgrowth.

[Journal of Human Genetics] SHARPIN showed aberrant cellular localization and reduced the activation of NF-κB, a central mediator of inflammatory and immune responses. Further investigation of the physiologic role of SHARPIN may reveal the mechanism of onset of late-onset Alzheimer’s disease.

[Journal of Experimental Medicine] Researchers observed that neutrophil DREAM repressed expression of A20, a negative regulator of NF-κB activity, and enhanced expression of pro-inflammatory molecules and phosphorylation of IκB kinase after TNF-α stimulation.