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obesity

Distinctive Features of Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease

[Digestive and Liver Disease] At variance with viral HCC, NAFLD-HCC shows a frequent association with cardiovascular co-morbidities, absence of cirrhosis in up to half of patients and an association with persistently normal transaminase values.

Clonal Hematopoiesis of Indeterminate Potential (CHIP): Linking Somatic Mutations, Hematopoiesis, Chronic Inflammation and Cardiovascular Disease

[Journal of Molecular and Cellular Cardiology] Investigators summarize emerging research on CHIP, the mechanisms underlying its important role in propagating inflammation and accelerating cardiovascular disease, and new studies detailing the role of associated risk factors and co-morbidities that increase CHIP prevalence.

Pro-Resolving Lipid Mediators: Regulators of Inflammation, Metabolism and Kidney Function

[Nature Reviews Nephrology] In self-limiting inflammation, the evolving inflammatory response is coupled to distinct processes that promote the resolution of inflammation and restore homeostasis.

Interferon-α-Producing Plasmacytoid Dendritic Cells Drive the Loss of Adipose Tissue Regulatory T Cells during Obesity

[Cell Metabolism] Researchers exploited the power of a visceral adipose tissue (VAT)-Treg TCR-transgenic mouse model to follow the dynamics of, and phenotypic changes in, the VAT-Treg population throughout the development of diet-induced obesity.

Severe Consequences of a High-Lipid Diet Include Hydrogen Sulfide Dysfunction and Enhanced Aggression in Glioblastoma

[Journal of Clinical Investigation] Because the environmental and lifestyle factors that impact CSC populations are not clear, scientists sought to understand the consequences of diet on CSC enrichment.

Dietary Carbohydrates and Fats in Nonalcoholic Fatty Liver Disease

[Nature Reviews Gastroenterology & Hepatology] Scientists review cross-sectional studies on dietary habits of patients with nonalcoholic fatty liver disease and randomized controlled trials on the effects of altering dietary macronutrients on intrahepatic triglyceride.

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