organoids

[iScience] Using colon cancer patient-derived organoids and xenografts, the authors identified rare long-term label-retaining quiescent CSCs that could re-enter the cell cycle to generate new tumors.

[Cell] Investigators established self-organizing cardioids from human pluripotent stem cells that intrinsically specified, patterned, and morphed into chamber-like structures containing a cavity.

[Cell] Scientists illuminated cell states, transcription factors, and organ-specific epithelial stem cell and mesenchyme interactions across lineages.

[Nature Communications] Researchers described a role for the Bcl-2 family member BAD in postnatal mammary gland morphogenesis that involves controlling localized translation and cell migration during gland development.

[Advanced Healthcare Materials] Investigators discuss advanced biomaterials where dynamic covalent chemistry is used to produce stable 3D cell culture models and high-resolution constructs for both in vitro and in vivo applications.

[mBio] Scientists used a human intestinal organoid model to define host transcriptional responses to S. Typhimurium infection, also determining host pathways dependent on Salmonella pathogenicity island- 1- and -2-encoded type 3 secretion systems