organoids

[JCI Insight] Investigators implemented novel patient-derived organoid and patient-derived xenografts strategies for high-throughput drug screening.

[Biochemical and Biophysical Research Communications] Researchers analyzed the association between the molecular characteristics which analyzed by next-generation sequencing and sensitivity to the ERK inhibitor in patient-derived organoids derived from colorectal cancer specimens.

[Oncology Letters] The authors demonstrated that chemical manipulation of esophageal keratinocyte differentiation in mouse normal esophageal epithelial organoids implicated the involvement of the mouse homologue of ZNF750, Zfp750, in keratinocyte differentiation in premalignant cells.

[Stem Cell Research & Therapy] Intestinal organoids derived from mouse small intestine were treated with vitamin D3, and the effects on intestinal stemness and differentiation were evaluated using real-time PCR and immunofluorescence staining of the distinct lineage markers.

[Advanced Materials] Finite element analysis served as a design tool to guide selection of geometries and material parameters for shape-matching 3D architectures tailored to organoids of interest.

[Clinical and Translational Gastroenterology] Investigators implemented novel patient-derived organoid and patient-derived xenografts strategies for high-throughput drug screening.