organoids

[Cell Stem Cell] The authors described a human multilineage iPSC-derived organoid that recapitulated cooperative cardiac and gut development and maturation, with extensive cellular and structural complexity in both tissues.

[Nature Genetics] Scientists benchmark of their endometrial organoids revealed the pathways and cell states regulating differentiation of the secretory and ciliated lineages both in vivo and in vitro.

[Communications Biology] Co-cultured using a magnetic spheroid formation approach, conditionally immortalised human podocytes and glomerular endothelial cells deposited mature, organized isoforms of collagen IV and Laminin.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] To address limitations in cell culture and in vivo mechanotransductive models, scientists developed two mouse lung organoid mechanotransductive models using postnatal day five mouse lung CD326-positive cells and fibroblasts subjected to increased, decreased, and cyclic strain.

[Lab On A Chip] Investigators developed a microfluidic organ-on-chip platform for matrix-based, heterogeneous 3D cultures with fully integrated electrochemical chemo- and biosensor arrays for the energy metabolites oxygen, lactate, and glucose.

[Molecular Oncology] The authors investigated whether drug responses of organoids correlated with clinical responses of matched patients and disease progression of patients.