organoids

[Cancer Research] Scientists showed follistatin-like 1 (FSTL1) expression to be closely correlated with activated fibroblasts and to be elevated in regenerative, fibrotic, and disease liver states in various mouse models. Consistently, FSTL1 lineage cells gave rise to myofibroblasts in a CCL4-induced hepatic fibrosis mouse model.

[Beneficial Microbes] The authors reported that the intestinal commensal microbe Limosilactobacillus reuteri ATCC PTA 6475 secretes 83.4 mM ethanol. Consistent with the activity of L. reuteri alcohol dehydrogenases, they found that L. reuteri tolerated various levels of ethanol.

[Stem Cells and Development] To associate the quality of kidney organoid differentiation with predictive markers, a ranking system was developed based on the ratio of nephron structure determined by histological examination.

[Oncotarget] Scientists performed a 24-hour treatment of a representative carcinogens cocktail in 37 independent organoid lines derived from normal colon biopsies.

[Science Immunology] To decipher immune recognition of human adenoviruse (HAdV) infection and determine new targets for immune-mediated control, researchers used an HAdV infection 3D organoid system, based on primary human intestinal epithelial cells.

[Journal of Molecular Biology] The authors review the importance of patient-derived tumor organoids as a model to study chromosomal instability in cancers of the gastrointestinal tract.